Immunobiological effects of fumonisin B1 in an experimental subchronic mycotoxicoses in rats.

THEUMER MG, LÓPEZ AG, MASIH DT, CHULZE SN AND RUBINSTEIN HR

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY.

Año: 2002 vol. 9 p. 149 - 149

1071-412X

b> Fumonisin B1 (FB1), the principal secondary metabolite produced by the fungus Fusarium verticillioidesFusarium verticillioides (Gibberella fujikuroi mating population A), is a potent toxin that can be found in fungus-contaminated corn and corn-based food products. We have investigated the immunobiological effects of subchronic dietary exposure to FB1 in male Wistar rats. Animals were fed with diets containing 0 (control) or 100 ppm of FB1 for 12 weeks. The total FB1 intake on day 90 was 810 mg/kg of body weight. Food consumption, body weight, and body weight gain on day 90 wer