Involvement of Nitric Oxide in Protecting Mechanism During Experimental Cryptococcosis.

ROSSI GR, CERVI L, GARCÍA MM, CHIAPELLO LS, SASTRE D AND MASIH DT.

CLINICAL IMMUNOLOGY

Elsevier

Año: 1999 vol. 90 p. 256 - 256

1521-6616

span lang="en" style="FONT-SIZE: 11pt; LINE-HEIGHT: 115%; FONT-FAMILY: "Calibri","sans-serif"; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: Calibri; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-fareast-language: EN-US; mso-bidi-language: AR-SA">In the present study we investigated the role of nitric oxide (NO) in the effector mechanisms of host defense against Cryptococcus neoformans in vivo. Our results showed an increase of NO produced by the peritoneal macrophages from 14-days infected rats compared with normal rats. These cells were capable of killing C. neoformans to a greater extent than macrophages from noninfected rats (80% vs 20%, respectively). The killing of C. neoformans by infected cells was efficiently inhibited (80% to 35%, P < 0.001) by adding aminoguanidine (AG) to the cultures. We observed t