Involvement of excretion-secretion products from Fasciola hepatica inducing suppression of the cellular immune response

CERVI LAP, RUBINSTEIN HR AND MASIH DT

VETERINARY PARASITOLOGY

Año: 1996 vol. 61 p. 97 - 97

0304-4017

b> Normal rats i.p. injected with Fasciola hepatica excretor-secretor antigen (ESA) induced a population of spleen mononuclear (SpM) cells, which suppressed the delayed type hypersensitivity (DTH) response to parasite antigens as well as to non-related antigens (human serum albumin) by adoptive transfer. A similar effect was observed when the cell transfer was performed with SpM cells non-adherent to nylon wool. The DTH was not modified by cells transfer adherent to nylon wool in syngeneic receptor animals. The observed suppression depended on the concentration and inoculation moment of the antigen; 1.8