Experimental coccidioidomycosis: effects of cyclophosphamide in immunologic responses.

RUBINSTEIN HR, MASIH DT, MARTICORENA B, RIERA CM.

MYCOPATHOLOGIA

Lugar: Holanda; Año: 1986 vol. 94 p. 91 - 91

0301-486X

span lang="en" style="FONT-SIZE: 9pt; FONT-FAMILY: Verdana; mso-fareast-font-family: "Times New Roman"; mso-bidi-font-family: "Times New Roman"; mso-ansi-language: EN-US; mso-fareast-language: ES; mso-bidi-language: AR-SA">Rats were infected with Coccidioides immitis and injected with cyclophosphamide three days pre or post infection. Administration of the drug before the infection caused enhancement of DTH response and decrease of the colony forming units (CFU). Conversely, injection of the drug three days post infection produced contrary effects, indicating that a normal T-cell function is essential as a defense mechanism in C. immitis infection