lmmunosuppression in Experimental Cryptococcosis: Variation of splenic and thymic populations and expression of class II major histocompatibility complex gen products

SOTOMAYOR C, RUBINSTEIN R, RIERA C, AND MASIH DT

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY

Año: 1995 vol. 77 p. 19 - 19

0090-1229

font face="Arial" size="1"> Previous studies from our laboratory have shown that infection with Cryptococcus neoformans can trigger the production of a series of suppressor cells that specifically inhibit the cell-mediated immune response to a nom-elated antigen, the human serum albumin (HSA). In the present study, we determined the variation of thymus and spleen cell populations in rats infected with C. neoformans and immunized with HSA-CFA at the time when suppressor activity was demonstrated. At 21 days postinfection, the number and the percentage of CD4?CDS? cells were significantly increased in the thymus together with a minor imbalance in other thymocytes subsets. The study of