Immunosuppression in experimental cryptococcosis in rats. Induction of afferent T suppressor cells to a non-related antigen.

SOTOMAYOR CE, RUBINSTEIN HR, RIERA CM, MASIH DT

JOURNAL OF MEDICAL AND VETERINARY MYCOLOGY

Lugar: Inglaterra; Año: 1987 vol. 25 p. 67 - 67

0268-1218

p class="MsoNormal" style="MARGIN: 12pt 0cm 0pt 42pt; LINE-HEIGHT: 14.4pt">To demonstrate the nature of the suppressor cells elicited in rats infected with Cryptococcus neoformans and immunized with human serum albumin (HSA), spleen mononuclear (SpM) cells were fractionated through a nylon wool column. The adherent and non-adherent populations were collected and transferred to syngeneic rats. In all cases, the non-adherent or T-enriched cells adoptively transferred suppression to HSA, however, the suppressive effects of the non-adherent cells were never as great as those of the unpassed population of SpM cells. The fractions adherent to nylon wool also diminished the delayed-type hypersensitivity response to HSA although this was not significant, but glass-adherent cells did exhibit significant suppressor activity. Immunized, non-infected rats were used as donor controls. Furthermore, we showed that