Effect of cyclophosphamide on rats experimentally infected with Cryptococcus neoformans.

RIERA CM, MASIH DT, RUBINSTEIN H, NOBILE R, VEGA VR.

MYCOPATHOLOGIA

Lugar: Holanda; Año: 1984 vol. 88 p. 127 - 127

0301-486X

p class="MsoNormal" style="MARGIN: 12pt 0cm 0pt 42pt; LINE-HEIGHT: 14.4pt">This study was undertaken to establish the function of T-lymphocytes in protective immunity against a cryptococcal infection in animals treated with Cyclophosphamide (Cy) pre or post infection and to determine how they relate to the progression of the disease. Inbred Suquia rats were infected either intranasally (i.n.) or intraperitoneally (i.p.) with 10(5) viable Cryptococcus neoformans cells. The infected rats were divided in three groups. One of the groups (group I) was utilized as a control. The second group (group II) was treated with Cy 3 days before the infection. The third group (group III) was treated with Cy 3 days after the infection. At approximately 22 days post infection, C. neoformans growth in selected organs of all animals were determined. In addition, humoral and delayed-type hypersensitivity (DTH) response