Experimental cryptococcosis in guinea pigs.

RIERA CM, MASIH DT, NOBILE R.

MYCOPATHOLOGIA

Lugar: Holanda; Año: 1983 vol. 82 p. 179 - 179

0301-486X

p class="MsoNormal" style="MARGIN: 12pt 0cm 0pt 42pt; LINE-HEIGHT: 14.4pt">A guinea pig model was used to evaluate immune response to Cryptococcus neoformans. This model shared characteristics with cryptococcosis in humans. Twenty five guinea pigs injected intraperitoneally with 10(7) viable C. neoformans cells developed disseminated disease. Forty days after infection all guinea pigs were killed and autopsy performed. C. neoformans growth in the lungs, brains, livers and spleen of the infected animals were determined. Furthermore, the immune response was characterized by moderate degree of delayed-type hypersensitivity and humoral response. In some organs was observed neutrophil and lymphocyte infiltration with presence of cryptococci cells. The infiltration observed in the organs was probably a consequence of an immune reaction.