Investigating Albendazole Desmotropes by Solid-State NMR Spectroscopy

ANA K. CHATTAH; RONGCHUN ZHANG; KAMAL H. MROUE; LAURA Y. PFUND; MARCELA R. LONGHI; A. RAMAMOORTHY; CLAUDIA GARNERO

AMER CHEMICAL SOC

Lugar: Washington; Año: 2015 vol. 12 p. 731 - 731

haracterization of the molecular structure and physicochemical solid-state properties of the solid forms of pharmaceutical compounds is a key requirement for successful commercialization as potential active ingredients in drug products. These properties can ultimately have a critical effect on the solubility and bioavailability of the final drug product. Here, the desmotropy of Albendazole forms I and II was investigated at the atomic level. Ultrafast magic angle spinning (MAS) solid-state nuclear magnetic resonance (NMR) spectroscopy, together with powder X-ray diffraction, thermal analysis, and Fourier transform infrared spectroscopy, were performed on polycrystalline samples of the two solids in order to fully characterize and distinguish the two forms. High-resolution one-dimensional 1H, 13C, and 15N together with two-dimensional 1H/1H single quantum?single quantum, 1H/1H single quantum?double quantum, and 1H/13C chemical shift correlation solid-state NMR experiments under MAS con