Application of 1D and 2D solid-state NMR spectroscopy to the characterization of morphine, morphine hydrochloride and their hydrates

ROMAÑUK, C.B.; GARRO-LINCK, Y.; ALVES DE SANTANA, M.S.; MANZO, R.H.; AYALA, A.P.; MONTI, G.A.; CHATTAH, A.K.; OLIVERA, M.E.

JOURNAL OF PHARMACEUTICAL SCIENCES

JOHN WILEY & SONS INC

Lugar: New York; Año: 2017 vol. 106 p. 3033 - 3033

0022-3549

he detailed knowledge of the solid forms of a drug is a key element in pharmaceutical development. Morphine, is an opiate alkaloidwidely used to treat severe acute and chronic pain. Much of the available information on its solid state dates from several decades ago. In order to obtain updated and reliable information1D and 2D solid-state NMR spectroscopy were used, and complemented with powder X-ray diffraction, FTIR and RAMAN spectroscopy and thermal analysis.13C CPMAS 1D spectra accomplish a complete identification of the related forms of morphine. Remarkably, 1H-13C heteronuclear correlation spectra together with FTIR results, gave clear evidence that neither morphine nor its hydrate crystallizes as a zwitterion. Our results indicate that the hydrogen bonds in the anhydrate forms have a different nature or strength than in their respective hydrates.