Artículos
Título:
Crystallographic, thermal and spectroscopic characterization of a ciprofloxacin saccharinate polymorph
Autor/es:
ROMAÑUK, CAROLINA B.; GARRO LINCK, YAMILA; CHATTAH, ANA KARINA; MONTI, GUSTAVO A.; GARLAND, M. T.; BAGGIO, R.; MANZO, R.H.; OLIVERA
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2010 vol. 391 p. 197 - 197
Resumen:
new polymorphic form of ciprofloxacin saccharinate (CIP-SAC II) is presented, and compared with CIPSAC
I, a different polymorph which we had previously reported. The characterization techniques used
were single crystal and powder X-ray diffraction, differential scanning calorimetry, thermogravimetry
analysis and infrared and 13C solid-state nuclear magnetic resonance spectroscopy. The results obtained
from these techniques are consistent. Differential scanning calorimetry and thermogravimetric analysis
showed that the reaction between the precursors is completed and the crystalline forms of both salts
obtained (I and II) are highly pure. Infrared spectroscopy gave clear evidence of a salt formation. Solidstate
nuclear magnetic resonance spectroscopy would indicate some degree of qualitative similarity in
the intermolecular interaction scheme in both polymorphs, while thermal analysis data might indicate
a difference in quantitative terms. A thorough single crystal structure