NMR and IR characterization of the aluminium complexes of norfloxacin and ciprofloxacin fluoroquinolones

ANA K. CHATTAH; YAMILA GARRO LINCK; GUSTAVO A. MONTI; PATRICIA R. LEVSTEIN; SUSANA A. BREDA; RUBÉN H. MANZO; MARÍA E. OLIVERA

MAGNETIC RESONANCE IN CHEMISTRY

John Wiley & Sons, Ltd.

Año: 2007 vol. 45 p. 850 - 850

0749-1581

font face="Palatino-Bold" size="1"> Aset of new aluminium complexes of norfloxacin (NOR) and ciprofloxacin (CIP) that show an improvement in their pharmaceutical properties were studied using solution and solid-state nuclear magnetic resonance (NMR) and infrared (IR) spectroscopy. The complexes synthesized with two different methods were compared. One of these methods will allow formulation of the compounds at production scale. High resolution 13C spectra were obtained with the cross-polarization and magic angle spinning (CP-MAS) experiment. These spectra were assigned by comparing them with the solution data of the pure drug and by using a quaternary carbon edition technique. The carbon relaxation times in the rotating frame, T1r