Inclusion complexes of beta-cyclodextrin and polymorphs of mebendazole: Physicochemical characterization

SAIDMAN, ELBIO; CHATTAH, ANA K.; ARAGÓN, LESLIE; SANCHO, MATÍAS; CAMÍ, GERARDO; GARNERO, CLAUDIA; LONGHI, MARCELA

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

ELSEVIER SCIENCE BV

Año: 2019 vol. 127 p. 330 - 330

0928-0987

ebendazole (MBZ), designated as a WHO essential drug, can exist in diverse solid forms and presents low absorption at the gastrointestinal level. Considering the potential of cyclodextrins to enhance the solubility and permeability of drugs, inclusion complexes of polymorphs A and C of MBZ with β‑cyclodextrin were obtained. The characterization of the complexes in solid state was performed by using a combination of experimental techniques including Fourier transform infrared spectroscopy, powder X-ray diffractometry and solid state nuclear magnetic resonance. Moreover, the effect of the binary complexes on their physical stability was evaluated. In addition, for a complete characterization of polymorphs A and C, one dimensional spectra and correlation nuclear magnetic resonance experiments were employed. Our physical studies showed that the inclusion complexes were new crystalline forms that induced shifts and broadening in the infrared and nuclear spectra. A molecular mode