LSP1-DEFICIENT MICE HAVE AN IMPAIRED CONTROL OF MELANOMA TUMOR GROWTH

Buenos Aires

Congreso; LXV Reunión de la Sociedad Argentina de Inmunología. II Reunión Conjunta de Sociedades de Biociencias; 2017

SOCIEDAD ARGENTINA DE INMUNOLOGIA

Leukocyte-specific protein 1 (LSP1) is a 52kDa cytoplasmic F-actinbinding phosphoprotein expressed in all human and murine leukocytesas well as in endothelial cells. LSP1 in known as an importantregulator of actin cytoskeleton remodeling. Our group haspreviously shown that Lsp1-/- mice have an impaired CTL responseafter antigen exposure, with Lsp1-/- dendritic cells (DCs) failing toinduce a strong CTL response in vivo, to migrate to lymphoid tissuesand to properly present antigens. To study the role of LSP1in antitumor immune response, we employed the MO5 melanomamodel. WT and Lsp1-/- mice were injected subcutaneously with 105MO5 cells and followed-up until day 26. Tumors in Lsp1-/- mice grewsignificantly faster and bigger than in WT mice...