Mannan from aloe saponaria inhibits tumoral cells activation and proliferation

ELSEVIER SCIENCE BV

Lugar: Omaha; Año: 2004 vol. 4 p. 411 - 411

font size="1" face="AdvTT5843c571"> In this study, we tested the antiproliferative effects of mannan from Aloe saponaria using normal murine (SpMC) and human cells (PBMC) and several tumoral cell lines. Employing flow cytometry, it could be determined that mannan inhibits the proliferative response in normal and tumoral cells. Mannan affects the expression of CD3+ SpMC indicating that mannan inhibits mainly T lymphocyte proliferative response. Also in SpMC cultured with or without mitogen mannan produces an increase of an activation marker (CD2