Synthesis, characterization and in vitro release studies of a new acetazolamideeHP-b-CD-TEA inclusion complex

GLADYS GRANERO; MARCOS MAITRE; CLAUDIA GARNERO; MARCELA LONGHI

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Año: 2008 vol. 43 p. 464 - 464

font size="1" face="AdvPSA88B"> Abstract The aim of our work was to develop a multicomponent inclusion complex of acetazolamide (ACZ) in order to investigate the combined effect of hydroxypropyl-b-cyclodextrin (HP-b-CD) and triethanolamine (TEA) on the solubility of ACZ and its possibility of ophthalmic delivery. Phase solubility study was used to evaluate the complexation in solution at 25 C. Complex formation was also evaluated by comparing the infrared (FT-IR) spectra of the solid complexes with a simple physical mixture containing the same amount of ACZ. FT-IR experiments provided data indicating that the carbonamido group of ACZ is involved in the inclusion process. In vitro release data showed that both formulations, containing the freeze-dried ternary