Study of Ascorbic Acid interaction with hydroxypropyl-B-cyclodextrin and triethanolamine, separately and in combination

GARNERO CLAUDIA; LONGHI MARCELA

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Año: 2007 vol. 45 p. 536 - 536

font size="1" face="Times-Roman"> Complexation between ascorbic acid, hydroxypropyl--cyclodextrin (HP--CD) and triethanolamine (TEA), separately and in combination,was studied in solution and solid state. The freeze-drying methodwas used to prepare solid complexes, while physical mixtures being obtained by simple blending. These complexes were characterized in the solid state using differential scanning calorimetry (DSC) and infrared spectroscopy (IR). Nuclear magnetic resonance spectroscopy (1H and 13C NMR) was used in aqueous solutions to obtain information about the mode of interaction. The degradation rate of each complex in solution was determined, and the stability constant of the complexes and the degradation rate of the