Resumen:
ome polymorphic drugs may undergo solid-state transformations as a result of storage and manufac- turing processes, which could have a significant impact on the performance characteristics of the drug. The present study was conducted as a strategy to provide information on clarithromycin polymorphs. The exhaustive characterization of solid form 0, an ethanol solvate, was performed starting with the develop- ment of a new synthesis route. The structural characterization was carried on by comparing the form 0 with the form II, the one currently used on the market. A variety of techniques, such as solid state nu- clear magnetic resonance, X-ray powder diffraction, infrared spectroscopy, thermoanalytical methods and confocal microscopy, were used to identify the form 0. These studies revealed important intermolecular interactions, as well as certain spatial and morphological particularities. The biopharmaceutical properties including solubility in water and simulated gastric fluid, and mi