Innovative technological systems to optimize the delivery and therapeutic activity of antimicrobial drugs

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents

Academic Press

Año: 2020; p. 105 - 139

Antimicrobial drugs are used to treat pathologies caused by different microorganisms. Although antimicrobials have saved countless lives, infections remain one of the leading causes of mortality. Therefore, it is relevant to optimize the pharmacotherapy available through the design of safe pharmaceutical formulations that improve efficacy, reduce the dose required and, the costs of antimicrobial therapy. The loss of efficacy of antimicrobials associated with resistant microorganisms, biofilms formers to pharmacological treatments, and the long and costly process for the development of new drugs, stimulates the implementation of investigations that allow a better use of approved drugs. Recently, the technological formulation approaches for improving drugs? bioavailability constitute one of the principal defiance for the pharmaceutical discipline. Advantageous approaches with promising properties have been developed. In particular, binary and multicomponent supramolecular systems, nanoparticles and self-emulsifying drug delivery systems that contribute to new alternatives for the treatment of infectious diseases.