Improving Delivery Systems through Supramolecular Complexes of Maltodextrin or Clyclodextrin and Furosemide Polymorphs

ANA KARINA CHATTAH; MARCELA LONGHI; CLAUDIA GARNERO

Río de Janeiro

Congreso; 18th ISMAR Meeting; 2013

Two critical factors responsible for the poor and highly vari- able human bioavailability of Furosemide polymorphs (a loop diuretic agent) are their low permeability and solubility. On the other side, selecting a proper polymorph and to control polymorphic transformations has a great impact in pharma- ceutical and regulation issues. With all these facts in mind, we have focused our work on preparing and characterizing new supramolecular systems of Furosemide polymorphs I and II with maltodextrin and cyclodextrins. Several techniques have been accomplished to study these complexes in the solution and solid state: spectroscopic tech- niques as solution and solid state NMR, FT-IR and XRPD, and also thermal analysis, and scanning electron microscopy. Relaxation times measurements ( 1H-T 1) have been decisive to confirm the formation of the complexes and to assess dif- ferences between them. In order to investigate the potential application of the supramolecular complexes as new delivery systems enhancing the bioavailability of the drug, solubility analysis and dissolution tests were used to correlate the per- formance between the polymorphic forms and the complexes.