Serum Levels of Adiponectin and Leptin in Children Born Small for Gestational Age: Relation to Insulin Sensitivity Parameters

MIRTA MIRAS, MARIANA OCHETTI, SILVIA MARTÍN, LILIANA SILVANO, GABRIELA SOBRERO, LAURA CASTRO, MARIANA ONASSIS, NORI TOLOSA DE TALAMONI, ADRIANA PÉREZ, GABRIELA PICOTTO, GABRIELA DÍAZ DE BARBOZA, LILIANA MUÑOZ

Zvi Zadik

Lugar: Jerusalen; Año: 2010 vol. 23 p. 463 - 463

hildren born small for gestational age (SGA) are prone to developing obesity, insulin resistance and type 2 diabetes. Adiponectin and leptin are adipocytokines associated with insulin sensitivity parameters. We aimed to relate serum adiponectin and leptin levels with insulin sensitivity parameters in prepuberal SGA children with and without catch-up growth (SGA+CUG; SGA-CUG, respectively) and to analyze the usefulness of these adipocytokines as early markers of insulin resistance. We analysed adiponectin, pro- insulin, leptin, growth factors, insulin, HOMA IR and HOMA βcell in 23 SGA+CUG, 26 SGA- CUG children compared with 48 prepuberal appropiate for gestational age (AGA). SGA children had adiponectin levels comparable to AGA children. Leptin levels were different between sexes, showed to be higher in SGA+CUG group (p=0.040) and these were significantly correlated with insulin sensitivity parameters. These results suggest leptin resis- tance as an adaptive mechanism to increase