Comparative analysis of clinical, biochemical and genetic aspects associated with bone mineral density in small for gestational age children

LILIANA SILVANO, MIRTA MIRAS, ADRIANA PÉREZ,GABRIELA PICOTTO, GABRIELA DÍAZ DE BARBOZA, LILIANA MUÑOZ, SILVIA MARTIN, GABRIELA SOBRERO, PEDRO ARMELINI, VERÓNICA MERICQ, NORI TOLOSA DE TALAMONI, AND COLLABORATING GROUP

Walter de Gruyter

Lugar: Berlin; Año: 2011 vol. 24 p. 511 - 511

inical, biochemical and genetic analysis related to bone mineral density (BMD) were carried out in children born small for gestational age (SGA) that failed to achieve post- natal catch-up growth (CUG), SGA children that completed CUG and adequate for gestational age (AGA) children. Serum IGF-I, IGF-II, IGF binding protein-3 and acid-labile subunit were lower in the SGA ? CUG children as compared with the other groups. Frequencies of polymorphic variants of vitamin D receptor, estrogen receptor and collagen genes were simi- lar among groups. The genotype 194 ? 192 of the IGF-I gene was higher in the SGA ? CUG and 196 ? 192 was higher in the SGA + CUG group. In the SGA ? CUG group, the genotype SS of the COLIA1 gene was associated with lower BMD. Therefore, IGF system and COLIA1 polymorphism distinguish prepu- bertal SGA ? CUG children from the SGA +C UG children of the same age. Furthermore, COLIA1 polymorphism could be useful to predict osteopenia in SGA ? CUG children.