Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action

SEBASTIÁN SUSPERREGUY, LILIANA MUÑOZ, NATALIA Y. TKALENKO, IVAN D. MASCANFRONI, VANINA A. ALAMINO, MARÍA M. MONTESINOS, ANA M. MASINI-REPISO, MIRTA B. MIRAS AND CLAUDIA G. PELLIZAS

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2011 vol. 74 p. 346 - 346

bjective Idiopathic short stature (ISS) describes short children with normal GH secretion. Although GH treatment increases their heights, growth response to the therapy differs among patients. Thyroid hormones (TH) are essential for longitudinal growth act- ing mainly through TH receptors (TR) a and b. We have previously reported that GH treatment reduced peripheral TH action in Turner Syndrome by TR down-regulation. The aims of the study were to assess the effect of GH treatment to ISS on peripheral TH action and the correlation between thyroid status and growth response to the therapy. Subjects, design and measurements Eighteen normal (con- trol) and twenty-five ISS children were enrolled and evaluated before and after 12 months of life time (control) or 12 months of GH therapy (ISS). Fasting blood was used for serum biochemical evaluations, peripheral blood mononuclear cells for TR mRNA determination by QRT-PCR and growth parameters by standard methods. Results GH treatment m