Establishment of Reference Ranges for Thyrotropin, Thyroxine, Free Thyroxine and Triiodothyronine in Neonates and Infants

LESCURAT, MP.; TARIFA, C.; AGUIRRE, MC.; COLLET, I.; SOBRERO, G.; SILVANO, L.; MARTIN, S.; OCHETTI, M.; MIRAS, M.; MUÑOZ, L.

Montevideo

Encuentro; XXIII Annual Meeting, SLEP Montevideo, Uruguay; 2012

Sociedad Latinoamericana de Endocrinología Pediátrica (SLEP)

Pediatric healthcare is critically dependent on the availability of accurate and precise reference intervals to allow appropriate clinical interpretation. Aims: To obtain reference intervals for TSH, T4, fT4 and T3 in a pediatric population from Córdoba, Argentina Subject and Methods: Serum samples of 410 healthy neonatesand infants (age range 4 to 365 days) were analyzed using electrochemiluminescentimmunoassay (cobas e 601). Results: No significant difference existed between the sexes. The percentile 2.5th, 50th and 97.5th were calculated for all reference groups. Conclusion: We report pediatric reference intervals for TSH, T4, fT4 and T3. It should assist pediatricians in interpreting these hormonal results more accurately and thereby lead to improve diagnosis of childhood thyroid diseases.