Associated Autoimmune Disease in Children with Recent Onset Type 1 Diabetes in a Cordoba Population

SILVANO, L.; BOYANOVSKY, A.; MARTIN, S.; PAZ POVEDADO, M.; RODRIGUEZ, P.; CASTRO, L.; SOBRERO, G.; MUÑOZ, L.; MIRAS, M.

Puerto Varas

Encuentro; XXV Annual Meeting of the Latin American Pediatric Endocrinology Society (SLEP); 2015

Sociedad Latinoamericana de Endocrinología Pediátrica (SLEP)

Background: There is wide variation in the prevalence of pancreatic and other major autoantibodies in different population of children with Type 1 Diabetes (T1DM). The frequency data of associated autoimmunity in children with T1DM in our population is limited. The aim of this study was to describe the frequency of specific beta-cell, thyroid and celiac auto antibodies in a caucasianpopulation of children at the clinical presentation with T1DM, from Cordoba Argentina between 2011 and 2015. Patients and Methods: We studied 126 children with T1DM aged ranged between 1.3?14.0 years (Female n = 61, Male n = 65)and mean BMI of 15.1 (13.7?28.2). We determined anti-GAD65, anti-IA2, anti Insuline (AI) antibodies by IRMA-Beckman Coulter, anti-TPO and anti-Tg by Elecsys-Roche, and anti-tTGA antibody by Elisa-Orgentec. Results: Anti-GAD65, anti-IA2 and anti-AI antibodies were positive in 67%, 62%, 36% respectively. The 15.5% of the patients presented the three autoantibodies positives and the 18.3% all negatives. Anti-TPO and anti-Tg were positive in 8% and 12%, respectively, with variation in the follow up. All of them were without treatment for the thyroid condition in this stage. Anti-tTGA antibody was positive in 15% for all the group of patients and not shown modification in the follow up of T1DM. We not observed significant difference in the prevalence of the analyzed antibodiesby sex. Conclusions: Our patient cohort exhibited higher prevalence of beta-cell autoimmunity compared with other populations. The knowledge of the presence of the autoantibodies and their behavior could contribute to the diagnosis and follow up the different associated autoimmune diseases in children with T1DM.