Establishment of Reference Ranges for Thyrotropin, Thyroxine, Free Thyroxine and Triiodothyronine in Neonates and Infants

DEL PILAR LESCURAT, MARIA; TARIFA, CINTIA; AGUIRRE, MARIA CECILIA; COLLET, IVAN; SOBRERO, GABRIELA; SILVANO, LILIANA; MARTÍN, SILVIA; OCHETTI, MARIANA; MIRAS, MIRTA; MUÑÓZ, LILIANA

Montevideo

Encuentro; XXIII Annual Meeting, SLEP; 2012

SLEP

ABSTRACT Pediatric healthcare is critically dependent on the availability of accurate and precise reference intervals to allow appropriate clinical interpretation. Aims: To obtain reference intervals for TSH, T4, fT4 and T3 in a pediatric population from Córdoba, Argentina. Subject and Methods: Serum samples of 410 healthy neonates and infants (age range 4 to 365 days) were analyzed using electrochemiluminescent immunoassay (cobas e 601). Results: No significant difference existed between the sexes. The percentile 2.5th, 50th and 97.5th were calculated for all reference groups. Conclusion: We report pediatric reference intervals for TSH, T4, fT4 and T3. It should assist pediatricians in interpreting these hor- monal results more accurately and thereby lead to improve diagno- sis of childhood thyroid diseases.