The acute inhibitory effects of iodide excess on sodium/iodide symporter expression and activity involve the PI3K/Akt signaling pathway

SERRANO-NASCIMENTO, C; DA SILVA TEIXEIRA, ; NICOLA, JP; NACHBAR, RT; CURI, R; MASINI-REPISO, AM; NUNEZ, MT

ENDOCRINE SOC

Año: 2014 vol. 155 p. 1145 - 1145

!--[if gte mso 9]> Iodide (I-) is an irreplaceable constituent of thyroid hormones and an important regulator of thyroid function, as high concentrations of I- downregulate NIS expression and function. In thyrocytes, PI3K/Akt pathway regulates NIS expression. Activation of PI3K/Akt inhibits NIS expression an