Synthesis of macroporous polymers with radical scavenging properties by immobilization of polyphenolic compounds

R. DARIO ARRUA; JUAN F. BASBUS; MIRIAM C. STRUMIA; ALVAREZ IGARZABAL, CECILIA I.,; MÓNICA A. NAZARENO

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2012 vol. 72 p. 807 - 807

olid phase radical scavengers have been prepared by the immobilization of antioxidant (AOX) compounds on macroporous polymers. Poly(glycidylmethacrylate-co-trimethylolpropane trimethacrylate) [poly(GMA TRIM)] and poly(N-acryloyl-tris(hydroxymethyl)aminomethane-co-glycidylmethacrylateco- N,N0-methylenebisacrylamide) [poly(NAT GMA BIS)] were prepared by free radical polymerization using a mixture of dimethylsulfoxide (DMSO)-poly(ethyleneglycol) 6000 (PEG 6000) as a porogenic solvent. The polymers were aminated with ethylenediamine (EDA) and the linkage of the polyphenolic compounds (gallic and caffeic acids) was carried out by two different approaches: through N,N0- dicyclohexylcarbodiimide/4-dimethylaminepyridine (DCC/DMAP) system (one-step method) or through the previous formation of the acyl chloride of the polyphenolic compounds and subsequent amidation reaction (two-step method). The available phenolic groups on the macroporous polymers were determined using the Folin Cio