Novel poly(NIPA-co-AAc) functional polymers for application in topical and oral drug delivery formulations

CUGGINO JC; CONTRERAS C; A. JIMENEZ-KAIRUZ; ALVAREZ IGARZABAL C.I.

AMER CHEMICAL SOC

Lugar: Washington; Año: 2014 vol. 11 p. 2239 - 2239

BSTRACT: The synthesis, characterization and properties of pH/thermosensitive hydrogels based on acrylic acid (AAc) and Nisopropylacrylamide (NIPA) using (+)-N,N′-diallyltartramide (DAT) as cross-linking agent and water as solvent, are presented in this article. Subsequently, the incorporation of ofloxacin (OFL) as model drug to evaluate the drug load capacity of hydrogels and the in vitro release from OFL-polymer conjugate are presented in order to define potential pharmaceutical applications. Interestingly, the incorporation of AAc diversified the properties of NIPA-based hydrogels allowing ionic interaction of these new materials with drugs of opposite charge and produced different release profiles at pH 1.2 and 6.8 simulated physiological media.