Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris (hydroxymethyl) aminomethane and N-isopropyl acrylamide

JULIO C. CUGGINO; MIRIAM STRUMIA ; CECILIA I. ÁLVAREZ IGARZABAL

ELSEVIER SCIENCE BV

Lugar: Belgica; Año: 2011 vol. 71 p. 440 - 440

font lang="en" size="1" face="AdvGulliv-R"> In this study, new hydrogels in rod shape were prepared from N-isopropyl acrylamide (NIPA), N-acryloyltris-(hydroxymethyl) aminomethane (NAT) and N,N0-methylenebisacrylamide (BIS). The effect of the incorporation of NAT into poly(N-isopropyl acrylamide) (PNIPA) structures for which the monomer composition was varied from NIPA 100% to NAT 100% was explored. The rheological studies were used to test their viscoelastic properties. Swelling experiments were used to test the capacity of water absorption, the modification of the network parameters, the swelling kinetics, the temperature and pH swelling response and n