Crosslinked soy protein films and their application as ophthalmic drug delivery system

AGUSTIN GONZALEZ; LUIS I. TARTARA; SANTIAGO D. PALMA; ALVAREZ IGARZABAL C.I.

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2015 vol. 51 p. 73 - 73

n this research, the potential of soy protein (SPI) based-films as drug delivery devices for ocular therapy was developed. Hence, crosslinked films with a natural and non-cytotoxic crosslinking agent, genipin (Gen), coatedwith poly(lactic acid) (PLA), were prepared. Filmogenic solutions were loaded with timolol maleate (TM) as a model drug, to be used as drug delivery devices, a novel application for this material. The mechanical properties of the filmswere studied, observing that with the presence of PLA coating, more rigid materialswith improved properties were obtained. Furthermore, the release behavior of TM was evaluated in aqueous medium, it being influenced by the degree of film crosslinking. Furthermore, it was determined that PLA coating decreased TM release rate compared to that of uncoated films. Similarly, this behavior was observed via indirect estimation of the release by assessing the hypotensive effectiveness of the films by in-vivo assays. Through intraocular press