Analytical and rheological studies of modified gel dosimeters exposed to X-ray beams

M. ROMERO; F. MATTEA ; J. VEDELAGO ; D. CHACON ; M. VALENTE ; C. ALVAREZ IGARZABAL ; M. STRUMIA

MICROCHEMICAL JOURNAL

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016 vol. 127 p. 231 - 231

0026-265X

he need to know the dose of X-rays to be applied to patients suffering diseases such as cancer requires accurate and stable dosimetric devices. Currently, the use of gelatin-based dosimeters has yielded excellent results but lack adequate thermal stability. In this paper a chemical modification of the gelatin (at concentrations typically used for the preparation of dosimeters) using glutaraldehyde as a cross-linking agent is proposed. Through rheological studies it was found that modified gelatin with glutaraldehyde concentrations between 0.15 and 0.50%w/v shows better thermal stability with an increase in elastic modulus of up to 100 times at 37 °C and convenient reaction times for the preparation of the dosimeters. Subsequently, a mathematical model to easily predict the elastic modulus of materials prepared with different concentrations of gelatin and glutaraldehyde was proposed.The analytical response of modified and unmodified materials was evaluated and no significant alteration