Redefining the chemistry of super-macroporous materials: when dendritic molecules meet polymer cryogels

GARCÍA SCHEJTMAN, SERGIO D.; MARZINI IRRANCA, SANTIAGO; ALVAREZ IGARZABAL, CECILIA I.; MARTINELLI, MARISA

Polymer Chemistry

The Royal Society of Chemistry

Año: 2020 vol. 11 p. 4507 - 4507

1759-9954

onsidering affinity chromatography as one of the main application areas of super-macroporous polymers, the selectivity and specificity of the interactions between the matrix and the specific substrate are critical. The combination of classical and dendritic monomers (DMs) then represents a novel alternative in which multivalent interactions are possible. In this context, the so-called cryogels (CGs) which are form from freezing-thawing processes represent an appealing alternative due to their effective mass transport and good mechanical properties. The aim of this work was to present a strategy to yield dendritic polymer-based cryogels (dCGs) according to a sustainable methodology, as a potential support for immunoglobulin G (IgG) purification. We describe here the synthesis and characterization of polyethylene glycol dimethacrylate (PEGDMA) based CGs obtained by their co-polymerization with acrylamide (AAm) or acrylic acid (AAc) and/or di-tert-butyl 4-amino-4-(3-(tert-butoxy)-3-oxopr