New thermo/ph -responsive materials containing ofloxacin. Preparation and physicochemical and invitro release behavior

CUGGINO JC, ; CONTRERAS C, ; JIMENEZ-KAIRUZ A, ; ALVAREZ IGARZABAL C

Cordoba

Congreso; RICiFA 2010: 1ª Reunión Internacional de Ciencias Farmacéuticas; 2010

-New hydrogels were prepared from NIPA, AAc and DAT. The effect of the incorporation of

AAc into polyNIPA structures was analyzed.

It was concluded that:

-The composition of monomers in the products and the temperature and pH of swelling

influenced the network parameters of the hydrogels.

-High drug loading was reached

-The release rate of Ofx and the kinetic control was sensible to change of pH dissolution medium.