Novel controlled release hydrogels formulation based on dendritic anionic polyelectrolyte-ciprofloxacin complexes

GARCÍA MC ; CUGGINO JC ; MANZO RH ; ÁLVAREZ IGARZABAL CECILIA; JIMENEZ-KAIRUZ AF

Rosario

Encuentro; RICIFA 2012 (2ª Reunión Internacional de Ciencias Farmacéuticas); 2012

Sociedad Argentina de Farmacia

Hydrogels are three-dimensional, cross-linked networks of water soluble polymers. A particular class of hydrogels is based on drug-polyelectrolite (D-PE) complexes, where a molecular dispersion of D is ionically bounded at the ionizable groups of PE. The unique phisical properties of these hydrogels place them as interesting systems to be used en controlled D delivery. Recently, a new anionic dendritic polylelectrolyte (DP) was synthesized by aqueous free-radical polymerization of a particularly prepared vinyl monomer derivate from Behera´s amine. In previous work, DP was considered as a potential non toxic material. Its complexes with Ciprofloxacin (Cip) showed acceptable microbiological activity versus Staphylococcus aureus y Pseudomona aeruginosa. This work is based on the evaluation of DP as a carrier of the antimicrobial Cip with potential use in topical and mucosal administration. Cip was selected as ionizable model drug because of its wide use in common topical opportunist infections.