Novel enteric coating based on acrylic/casein dispersions for smart delivery systems

M.L. PICCHIO ; A.J. PAREDES; S.D. PALMA ; M.C.G. PASSEGGI JR. ; L.M. GUGLIOTTA; R.J. MINARI; C.I. ALVAREZ IGARZABAL

Bahia Blanca

Workshop; III Workshop de Polímeros Biodegradables y Biocompuestos, Biopoli 2018; 2018

Plapiqui

The use of bio-based polymers to prepare pharmaceuticals and biomedical agents has generated considerable research interest in recent years Strict health regulations and consumers preferences have driven the use of natural polymers due to their recognized non-toxicity as vehicles. In this context, relevant characteristics of casein protein as biocompatibility, ability for binding ions and small molecules, and water binding capacities, turn this material an attractive option. Moreover, the amino acid composition in casein confers it a pH-responsive behavior, which could be used to design programmable-release materials. In view of this, acrylic/casein hybrid films appear as an excellent alternative as functional coating. This work aimed to prepare film-forming dispersions for smart drug delivery systems based on acrylic/casein nanoparticles using highly methacrylated protein as macro-crosslinker. The targeted application of the obtained films as functional carriers was evaluated using bovine serum albumin (BSA) and ofloxacin (OFL) as model drugs.