Novel hydrogels based on new dendritic polymers as antimicrobial carrier systems

GARCÍA MÓNICA C; CUGGINO JULIO C ; ROSSET CLARISA I; STRUMIA MIRIAM C; MANZO RUBEN H ; ALOVERO FABIANA L; ALVAREZ IGARZABAL CECILIA I ; JIMENEZ-KAIRUZ ALVARO F

Madrid

Conferencia; Pharmaceutics & Novel Drug Delivery Systems; 2016

OMICS

Hydrogels are usually defined as a crosslinked polymeric network having the capacity of holding large amount of water within itsporous structure. Those comprise an important class of biomaterials specially used for drug delivery applications, due to theirbiocompatibility, good rheological and bioadhesive properties, high capacity of loaded drug and modified-release behaviors. Thiswork reports the development of an antibacterial delivery system, under hydrogel form, based on a novel biocompatible dendronizedpolyelectrolyte (DP) as a carrier of ciprofloxacin (CIP). The ionic complexes of DP-CIP were formed by acid-base reaction using thehigh density of acid groups of the dendronized polymer and the amine groups of the ciprofloxacin drug. Hydrogels based on DPCIPwere easily prepared and showed excellent mechanical properties without dermal irritation for topical administration. A slowand diffusion-controlled in-vitro release of CIP towards simulated physiological fluids was observed. The release performance couldbe attributed to the ion exchange phenomenon, revealing that the release of CIP from these hydrogels was appropriate, in terms ofboth magnitude and velocity. In-vitro bacterial growth inhibition assay showed a significant CIP activity, corresponding to 38 and58 % compared to that exhibited by CIP hydrochloride solution at similar CIP concentrations, against S. aureus and P. aeruginosa,respectively. In addition, the high biocompatibility of hydrogel was demonstrated by in-vivo skin irritancy test. The hydrogel basedon DP-CIP showed particularly promising properties that could be exploited for the treatment of topical and mucosal opportunisticinfections in human or veterinary applications.