Therapeutic supramolecular networks integrating casein micelles for controlled topical drug delivery

BONAFÉ ALLENDE, J. C.; AMBROSIONI, F.; SOLER, M. F. ; PICCHIO, M.; MINARI, R. J.; MONTESINOS, M. M.; JIMENEZ KAIRUZ, A.; ALVAREZ IGARZABAL, CECILIA INES

Buenos Aires

Simposio; XIII Simposio Argentino de Polímeros - SAP 2019; 2019

Sociedad Argentino de Polímeros

The aim of this work was preparing PVA/PGA supramolecular networks integrating SSD loaded-crosslinked casein micelles (CCM) for application as topical drug delivery system in wound healing. Trihydroxibenzoic acid (gallic acid) was used to modify the CCM aiming to improve their dispersability into the supramolecular matrix. These nanoparticles-containing supramolecular materials could be applied in liquid state at 37ºC on the damaged zone and then, in situ gelation can occur at the skin temperature (33ºC). The supramolecular binder, PGA, can act as therapeutic drug due to the anti-inflammatory and antibacterial properties of this compound. The controlled diffusion of PGA from the supramolecular matrix to the injury changes the viscoelastic properties of the network which could trigger the release of the SSD-loaded CCM. Then, the CCM can be degraded by the presence of MMPs, achieving thus the specifically release of the pharmaceutical molecule at wound site.